Genes

Methylation and expression analysis of mismatch repair genes in extramammary Paget's disease

Background

Extramammary Paget's disease (EMPD) is a rare skin cancer with relative high frequencies of germline and somatic mismatch repair (MMR) genes mutations. However, the methylation and expression of these genes have not been validated in EMPD.

Objective

This study aims to confirm the methylation and expression of MMR genes in EMPD.