Extramammary Paget's Disease (EMPD) Drugs

 

 

Are there any drug treatments for EMPD?

Extramammary Paget's disease (EMPD) is very rare and because of this the cancer does not currently have any dedicated drugs that have been formulated and tested specifically for EMPD use. However, it is not unusual, in many countries, that once a pharmaceutical is approved for a particular use, doctors may also use the same drug in an “off-label” manner for other treatments. Without a focus on EMPD, patients have been relying on the success of other cancer treatments. There is hope that this could change in the future.

Some medical institutions are now using genomic testing on a patient’s EMPD to determine what DNA mutations may exist within the EMPD tumor. With this information, physicians can determine if a person’s EMPD cancer might be susceptible to other known treatments that have been used on similar mutations.

Memorial Sloan Kettering Cancer Center (MSKCC) is a leader in next generation targeted therapies. The MSK IMPACT program – which stands for integrated mutation profiling of actionable cancer targets – was approved by the US Food and Drug Administration in 2017. It is now being used routinely by EMPD patients at MSKCC. It is hoped that as more data on EMPD is obtained, and shared, a clearer course of EMPD treatment will be formulated.

Even without specific EMPD targeted drugs, the following pharmaceuticals have been used, with varied levels of success, on EMPD patients. The name or the availability of a drug can vary by country or region.

Adrucil

Other Names: 5-fluorouracil , 5-FU, Carac, Fluorouracil (5FU), Fluoroplex, Efudex, and Tolak

Summary: Fluorouracil (5FU) is a chemotherapy drug. It is often used to treat breast, bowel, skin, gastrointestinal, oesophageal, and pancreatic cancers. In topical use (cream or solution) it is sometimes used on basal cell cancer and actinic keratoses.

Aldara

Generic Name: Imiquimod

Other Names: Perrigo, Zyclara

Summary: Aldara is a an immune response modifier used to treat actinic keratoses, basal cell carcinoma (BCC), intraepidermal carcinomas, squamous cell carcinoma (SCC) and genital warts. Imiquimod stimulates the immune system to release cytokines. More information on Aldara (Imiquimod) can be found on the Non-Surgical EMPD Treatments page.

Arimidex

Generic Name: Anastrozole

Summary: Arimidex is an oral hormone therapy for breast cancer in postmenopausal women.

Casodex

Generic Name: Bicalutamide

Summary: Casodex is an oral non-steroidal anti-androgen hormone therapy for prostate cancer.

Docetaxel

Other Names: Taxotere, Docefrez

Summary: Docetaxel is used in treatment of breast cancer, non-small cell lung cancer, advanced stomach cancer, head and neck cancer and metastatic prostate cancer. It is also being investigated to treat small cell lung, ovarian, bladder, and pancreatic cancers, soft tissue sarcoma and melanoma.

Eligard

Generic Name: Leuprolide

Other Names: Lupron, Lupron Depot, Viadur

Summary: Eligard is a hormone therapy. Eligard is used to treat prostate, breast, ovarian and endometrial cancers.

Herceptin

Generic Name: Trastuzumab

Other Names: Herzuma (Biosimilar)

Summary: Herceptin is a monoclonal antibody. Herceptin is used to treat metastatic breast cancer. It is most effective against tumors that have the HER2/neu protein.

Imlygic

Generic Name: Talimogene Laherparepvec

Other Names: T-VEC

Summary: Imlygic is a biopharmaceutical drug used to treat melanoma lesions that cannot be operated on.

Nerlynx

Generic Name: Neratinib

Summary: Nerlynx is an anti-cancer (antineoplastic) chemotherapy drug used on breast cancer.

Opdivo

Generic Name: Nivolumab

Summary: Nivolumab is a targeted therapy. It is a human programmed death receptor-1 (PD-1) blocking antibody. It is used to treat metastatic melanoma, non-small cell lung cancer (NSCLC), advanced renal cell cancer, Hodgkins lymphoma (cHL), etastatic squamous cell carcinoma of the head and neck (SCCHN), metastatic small cell lung cancer (SCLC) and hepatocellular cancer (HCC).

Paraplatin

Generic Name: Carboplatin

Summary: Carboplatin is an anticancer drug chemotherapy drug used to treat ovarian, lung, head and neck, endometrial, esophageal, bladder, breast, and cervical cancers.

Projecta

Generic Name: Pertuzumab

Summary: Projecta is used to treat HER2-positive breast cancer.

Taxol

Generic Name: Paclitaxel

Other Names: Onxal, Abraxane

Summary: Taxol is a chemotherapy drug. It is often used to treat breast, ovarian, lung, bladder, prostate, melanoma, esophageal, and other types of solid tumor cancers.

This list was created from varied EMPD patients. The listing should not be used to formulate any EMPD treatment and is not intended as a substitute for the medical advice of a physician.