Extramammary Paget's Disease (EMPD) Chemotherapy
Are there any drug treatments for EMPD?
Extramammary Paget's disease (EMPD) is very rare and because of this the cancer does not currently have any dedicated chemotherapies that have been formulated and tested specifically for EMPD use. However, it is not unusual, in many countries, that once a pharmaceutical is approved for a particular use, doctors may also use the same drug in an “off-label” manner for other treatments. Without a focus on EMPD, patients have been relying on the success of other cancer treatments. There is hope that this could change in the future.
Some medical institutions are now using genomic testing on a patient’s EMPD to determine what DNA mutations may exist within the EMPD tumor. With this information, physicians can determine if a person’s EMPD cancer might be susceptible to other known treatments that have been used on similar mutations.
Memorial Sloan Kettering Cancer Center (MSKCC) is a leader in next generation targeted therapies. The MSK IMPACT program – which stands for integrated mutation profiling of actionable cancer targets – was approved by the US Food and Drug Administration in 2017. It is now being used routinely by EMPD patients at MSKCC. It is hoped that as more data on EMPD is obtained, and shared, a clearer course of EMPD treatment will be formulated.
Even without specific EMPD targeted drugs, the following pharmaceuticals have been used, with varied levels of success, on EMPD patients. The name or the availability of a drug can vary by country or region.
Generic Name: Doxorubicin
Other Name: Rubex
Summary: Adriamycin is an anthracycline antibiotic chemotherapy drug used to treat lymphomas, leukemias, bone sarcoma, breast cancer, endometrial cancer, gastric cancer, liver cancer, kidney cancer, multiple myeloma, neuroblastoma, ovarian cancer, small cell lung cancer, and thyroid cancer.
Other Names: 5-fluorouracil , 5-FU, Carac, Fluorouracil (5FU), Fluoroplex, Efudex, and Tolak
Summary: Fluorouracil (5FU) is a chemotherapy drug. It is often used to treat breast, bowel, skin, gastrointestinal, oesophageal, and pancreatic cancers. In topical use (cream or solution) it is sometimes used on basal cell cancer and actinic keratoses.
Generic Name: Imiquimod
Other Names: Perrigo, Zyclara
Summary: Aldara is a an immune response modifier used to treat actinic keratoses, basal cell carcinoma (BCC), intraepidermal carcinomas, squamous cell carcinoma (SCC) and genital warts. Imiquimod stimulates the immune system to release cytokines. More information on Aldara (Imiquimod) can be found on the Non-Surgical EMPD Treatments page.
Generic Name: Anastrozole
Summary: Arimidex is an oral hormone therapy for breast cancer in postmenopausal women.
Generic Name: Bicalutamide
Summary: Casodex is an oral non-steroidal anti-androgen hormone therapy for prostate cancer.
Generic Name: Cyclophosphamide
Other Name: Neosar
Summary: Cytoxan is an alkylating chemotherapy often used to treat lymphomas, leukemias, multiple myeloma, neuroblastoma, retinoblastoma, breast cancer, and ovarian cancer.
Other Names: Taxotere, Docefrez
Summary: Docetaxel is used in treatment of breast cancer, non-small cell lung cancer, advanced stomach cancer, head and neck cancer and metastatic prostate cancer. It is also being investigated to treat small cell lung, ovarian, bladder, and pancreatic cancers, soft tissue sarcoma and melanoma.
Generic Name: Leuprolide
Other Names: Lupron, Lupron Depot, Viadur
Summary: Eligard is a hormone therapy. Eligard is used to treat prostate, breast, ovarian and endometrial cancers.
Generic Name: Epirubicin
Summary: Epirubicin is a chemotherapy drug often used in treating breast cancer.
Generic Name: Gemcitabine
Summary: Gemzar is a chemotherapy drug often used in treating pancreas cancer, non-small cell lung cancer, bladder cancer, soft-tissue sarcoma, metastatic breast cancer and ovarian cancer.
Generic Name: Trastuzumab
Other Names: Herzuma (Biosimilar)
Summary: Herceptin is a monoclonal antibody. Herceptin is used to treat metastatic breast cancer. It is most effective against tumors that have the HER2/neu protein.
Generic Name: Talimogene Laherparepvec
Other Names: T-VEC
Summary: Imlygic is a biopharmaceutical drug used to treat melanoma lesions that cannot be operated on.
Generic Name: Neratinib
Summary: Nerlynx is an anti-cancer (antineoplastic) chemotherapy drug used on breast cancer.
Generic Name: Nivolumab
Summary: Nivolumab is a targeted therapy. It is a human programmed death receptor-1 (PD-1) blocking antibody. It is used to treat metastatic melanoma, non-small cell lung cancer (NSCLC), advanced renal cell cancer, Hodgkins lymphoma (cHL), etastatic squamous cell carcinoma of the head and neck (SCCHN), metastatic small cell lung cancer (SCLC) and hepatocellular cancer (HCC).
Generic Name: Carboplatin
Summary: Carboplatin is an anticancer drug chemotherapy drug used to treat ovarian, lung, head and neck, endometrial, esophageal, bladder, breast, and cervical cancers.
Generic Name: Cisplatin
Summary: Cisplatin is a chemotherapy drug often used in treating bladder cancer, metastatic ovarian cancer, and metastatic testicular cancer.
Generic Name: Pertuzumab
Summary: Projecta is used to treat HER2-positive breast cancer.
Generic Name: Paclitaxel
Other Names: Onxal, Abraxane
Summary: Taxol is a chemotherapy drug. It is often used to treat breast, ovarian, lung, bladder, prostate, melanoma, esophageal, and other types of solid tumor cancers.
This list is created from varied extramammary Paget's disease (EMPD) patients. The listing should not be used to formulate any EMPD treatment and is not intended as a substitute for the medical advice of a physician.